There are many
riddles to unravel in studying the origins of life. One recent major change in
the literature is the use of the plural ‘origins’ rather than the singular
‘origin’. Several years ago, a major journal in the field changed the first
word in its name by pluralizing the singular. It is now Origins of
Life and Evolution of the Biosphere, to account for multiple origin
hypotheses.
One long-standing
argument that divided the field for a time was whether genes came first or
metabolism came first. Over the last decade there has been a détente in the two
camps realizing that they both genetics and metabolism likely co-evolved,
however the details are still poorly understood. The latest foray into bridging
the camps is an article in Foundations of Science by John Stewart titled
“The Origins of Life: The Managed-Metabolism Hypothesis”.
The crux of the
argument is that a proto-metabolism by itself is highly unlikely to evolve into
a more complex life-like system because of a ‘cooperative barrier’. Two key
contributions to this barrier are (1) the inability to support ‘beneficial
cooperators’ (molecules that catalyze the formation of other molecules within
the autocatalytic proto-metabolism) that themselves are not produced within the
system, and (2) ‘free rider’ molecules that reduce the concentrations of
molecules participating in the metabolism, which essentially behave as
parasites.
How could one
imagine taking the next leap of complexity? Stewart’s answer is that the
evolution of ‘managed chemistry’ is required. In particular, he argues that a
separate digital-encoded system, that is to a large extent independent of the
proto-metabolism but benefits from it and can direct resources, would be able
to drive a phase-change so-to-speak of non-life to life-like. How exactly this
works isn’t clear. It is a hypothesis paper after all. From my reading (and I
might not have fully understood the details), it attempts to graft the RNA
World approach on to an early proto-metabolism that then allows for co-evolution.
The theory takes inspiration from organizational features of living systems
including societies and corporations. I previously theorized tongue-in-cheek
about the role of managers as reducers of thermodynamic complexity. Stewart hints at this line of thought – ‘chemical system managers’ allows for
more efficient energy dissipation thus driving the co-evolution of the system.
The article
attempts to posit analogies between chemical managers and corporate (presumably
human) managers in society. For example, one might consider government as an
organizing system that evolved from a loose association of tribes and
individuals who pool their resources to increase their energy efficiency.
Specialization takes place and, before you know it, we’re no longer disparate
small groups of hunter-gatherers but urban dwellers compressed into a small
space – a buzzing hive of activity. If you were to estimate the energy use per
capita in an urban area, the efficiency is likely higher than in the rural
areas despite the idyllic picture of living-out-there in nature. Remember we’re
talking about efficient energy use as a total sum and being able to direct
‘excess’ energy into other products and activities. Cities are good at that,
despite their problems.
Stewart makes some
suggestions of how his hypothesis can be tested, and how it differs from other
seemingly related hypotheses that he thinks have their flaws. He’s not very
specific about how one should go about this, so I’m not sure who might take
this up. But it’s an interesting idea nevertheless. It has also made me think
about management in a slightly different way. Now when I think about
administrators and managers, I’m going to start imagine them as molecules in a
system! Hmmm… I wonder what molecules will represent them. Might depend on
their different personalities and idiosyncracies, and whether they are foxes or hedgehogs. I just talked about some properties of polar versus non-polar
molecules today in my general chemistry course. Maybe some managers are like polar molecules and others are
like non-polar molecules. Perhaps I’ll have strange dreams tonight about them.
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